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7-Chlorokynurenic acid
CAS No. 18000-24-3
7-Chlorokynurenic acid ( 7-CKA | 7-chloro-4-hydroxy-2-carboxyquinoline )
产品货号. M26039 CAS No. 18000-24-3
7-Chlorokynurenic Acid 是一种有效的选择性 NMDA 受体拮抗剂，对甘氨酸 B 共激动剂位点的 IC50 为 0.56 μM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥308 | 有现货 |
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| 10MG | ￥494 | 有现货 |
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| 25MG | ￥1037 | 有现货 |
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| 50MG | ￥1985 | 有现货 |
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| 100MG | ￥3831 | 有现货 |
|
| 500MG | ￥7995 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称7-Chlorokynurenic acid
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述7-Chlorokynurenic Acid 是一种有效的选择性 NMDA 受体拮抗剂，对甘氨酸 B 共激动剂位点的 IC50 为 0.56 μM。
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产品描述7-Chlorokynurenic acid is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery.(In Vivo):In male Sprague-Dawley rats, 7-Chlorokynurenic acid (10 nM) retardates the development of both the electroencephalographic and motor (17.7 daily stimulations) components of the seizure response.
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体外实验——
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体内实验Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.
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同义词7-CKA | 7-chloro-4-hydroxy-2-carboxyquinoline
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通路Neuroscience
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靶点GluR
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受体CDK
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研究领域——
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适应症——
化学信息
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CAS Number18000-24-3
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分子量223.61
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分子式C10H6ClNO3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 16.67 mg/mL (74.55 mM)
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SMILESO=C(O)C=1N=C2C=C(Cl)C=CC2=C(O)C1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Okusaka T, Ueno H, Ikeda M, Takezako Y, Morizane C. Phase I study of TAC-101, an oral synthetic retinoid, in Japanese patients with advanced hepatocellular carcinoma. Cancer Sci. 2012 Aug;103(8):1524-30. doi: 10.1111/j.1349-7006.2012.02334.x. Epub 2012 Jun 18. PubMed PMID: 22587457.
